UBP 302 | iGluR antagonist | Probechem Biochemicals

Chemical Structure : UBP 302

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UBP 302 (UBP-302, UBP302, (S)-UBP 296)

货号: PC-60771Not For Human Use, Lab Use Only.

UBP 302 (UBP-302) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 402 nM.

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生物&药学活性

UBP 302 (UBP-302) is a potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 402 nM.
UBP 302 displays about 260-fold selectivity over AMPA receptors, 90-fold selectivity over recombinant human GLUK6- and GLUK2-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors.
UBP 302 blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers.
UBP 302 also protects against soman-induced seizures and neuronal degeneration in vivo.

物理化学性质&存储条件

分子量	333.3
分子式	C15H15N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione

参考文献

1. More JC, et al. Neuropharmacology. 2004 Jul;47(1):46-64.

2. Mayer ML, et al. J Neurosci. 2006 Mar 15;26(11):2852-61.

3. Apland JP, et al. Neuroscience. 2009 Mar 3;159(1):380-9.

4. Andreou AP, et al. Br J Pharmacol. 2009 Jun;157(3):464-73.

UBP 302 (UBP-302, UBP302, (S)-UBP 296)

生物&药学活性

物理化学性质&存储条件

参考文献

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UBP 302 (UBP-302, UBP302, (S)-UBP 296)

生物&药学活性

物理化学性质&存储条件

参考文献

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