UBE2M-DCN1 inhibitor 52 |CAS:2089293-14-9 Probechem Biochemicals

Chemical Structure : UBE2M-DCN1 inhibitor 52

加入收藏

UBE2M-DCN1 inhibitor 52

货号: PC-63291Not For Human Use, Lab Use Only.

UBE2M-DCN1 inhibitor 52 is a highly potent inhibitor of DCN1-UBE2M protein-protein interaction with IC50 of 60 nM, inhibits cullin neddylation in pulse-chase NEDD8 transfer assay with EC50 of 80 nM.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

UBE2M-DCN1 inhibitor 52 is a highly potent inhibitor of DCN1-UBE2M protein-protein interaction with IC50 of 60 nM, inhibits cullin neddylation in pulse-chase NEDD8 transfer assay with EC50 of 80 nM.
UBE2M-DCN1 inhibitor 52 binds to DCN1 and selectively reduce steady-state levels of neddylated CUL1 and CUL3 in a squamous cell carcinoma cell line.
UBE2M-DCN1 inhibitor 52 inhibits DCN1 but not DCN3 stimulated NEDD8 transfer from UBE2F to the cullins.

物理化学性质&存储条件

分子量	447.546
分子式	C25H32F3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Benzyl-1-(1-(pentan-2-yl)piperidin-4-yl)-3-(3-(trifluoromethyl)-phenyl)urea

参考文献

1. Hammill JT, et al. J Med Chem. 2018 Apr 12;61(7):2680-2693.