UBCS373 | Sirtuin 4 inhibitor | Probechem Biochemicals

Chemical Structure : UBCS373

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UBCS373 (Sirt4 inhibitor 69)

货号: PC-21715Not For Human Use, Lab Use Only.

UBCS373 (Sirt4 inhibitor 69) is a highly isoform selective inhibitor of mitochondrial deacylase Sirtuin 4 (Sirt4) with IC50 of 16 uM.

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生物&药学活性

UBCS373 (Sirt4 inhibitor 69) is a highly isoform selective inhibitor of mitochondrial deacylase Sirtuin 4 (Sirt4) with IC50 of 16 uM.
UBCS373 displays high selectivity against Sirt1, −2, −3, −5, and −6.
UBCS373 inhibits Sirt4 through binding to active site regions overlapping with the acyl-peptide binding regions but not with the NAD+ site.
UBCS373 dose-dependently increases GDH activity in both whole cells and mitochondrial extract of C2C12 mouse myoblast cells.
UBCS373 is active in cells and can serve as a chemical tool for physiological studies on Sirt4.

物理化学性质&存储条件

分子量	503.52
分子式	C19H13N5O6S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-((4-Nitrophenyl)sulfonyl)thiazol-2-yl)-2-((4-oxo-3,4-dihydroquinazolin-2-yl)thio)acetamide

参考文献

1. Martin Pannek, et al. J Med Chem. 2024 Jan 22. doi: 10.1021/acs.jmedchem.3c01496.

UBCS373 (Sirt4 inhibitor 69)

生物&药学活性

物理化学性质&存储条件

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UBCS373 (Sirt4 inhibitor 69)

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