UBASHIN-5 | UBASH3B inhibitor | Probechem Biochemicals

Chemical Structure : UBASHIN-5

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UBASHIN-5 (LIT-14-132)

货号: PC-28293Not For Human Use, Lab Use Only.

UBASHIN-5 (LIT-14-132) is a small-molecule inhibitor targeting UBASH3B 2HP domain, disrupts mitotic localization of UBASH3B and Aurora B, seletively induces arrest and cell death during mitosis without toxicity to normal cells, selectively suppresses breast and colon tumor growth in vivo.

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生物&药学活性

UBASHIN-5 (LIT-14-132) is a small-molecule inhibitor targeting UBASH3B 2HP domain, disrupts mitotic localization of UBASH3B and Aurora B, seletively induces arrest and cell death during mitosis without toxicity to normal cells, selectively suppresses breast and colon tumor growth in vivo.

物理化学性质&存储条件

分子量	1128.29
分子式	C41H43ClF17N11O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(4-((7R,10R)-10-benzyl-13-(4-chlorophenyl)-7-(3-guanidinopropyl)-3,6,9,12-tetraoxo-2,5,8,11-tetraazatridecyl)-1H-1,2,3-triazol-1-yl)ethyl)-4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecanamide TFA salt

参考文献

1. Pangou E, et al. EMBO Mol Med. 2026 Sep 22. doi: 10.1038/s44321-026-00519-0.

UBASHIN-5 (LIT-14-132)

生物&药学活性

物理化学性质&存储条件

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UBASHIN-5 (LIT-14-132)

生物&药学活性

物理化学性质&存储条件

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