UB-ALT-P2

Chemical Structure : UB-ALT-P2

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货号: PC-26569Not For Human Use, Lab Use Only.

UB-ALT-P2 is a potent and selective brain-penetrant negative allosteric modulator / antagonist of ATP-gated P2X7 receptor (P2X7R) with IC50 of 1.3 nM.

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生物&药学活性

UB-ALT-P2 is a potent and selective brain-penetrant negative allosteric modulator / antagonist of ATP-gated P2X7 receptor (P2X7R) with IC50 of 1.3 nM.
UB-ALT-P2 inhibits agonist-induced calcium influx through human, rat, and mouse P2X7Rs with IC50 of 0.38 nM, 130 nM and 35 nM respectively.
UB-ALT-P2 blunts weight loss, improves short- and long-term memory, reduces amyloid-β plaque burden, lowers hyperphosphorylated tau, and diminishes oxidative and inflammatory markers in the 5xFAD mouse model of AD.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Turcu AL, et al. bioRxiv [Preprint]. 2026 Apr 8:2026.04.06.716621.

UB-ALT-P2

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物理化学性质&存储条件

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UB-ALT-P2

生物&药学活性

物理化学性质&存储条件

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