UAWJ172 | Enterovirus 2C inhibitor | Probechem Biochemicals

Chemical Structure : UAWJ172

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UAWJ172 (UAWJ 172)

货号: PC-20016Not For Human Use, Lab Use Only.

UAWJ172 is a potent and broad-spectrum inhibitor against enterovirus with IC50 of 0.1-0.8 uM agianst EV-D68, EV-A71 and CVB3 strains, targets viral 2C protein.

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100 mg		Get quote

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生物&药学活性

UAWJ172 is a potent and broad-spectrum inhibitor against enterovirus with IC50 of 0.1-0.8 uM agianst EV-D68, EV-A71 and CVB3 strains, targets viral 2C protein.
UAWJ172 inhibits plaque formation of EV-D68 US/MO/14-18947 with EC50 of 25 nM.
UAWJ172 exhibits broad-spectrum antiviral activity against EV-D68, EV-A71, and CVB3.
UAWJ172 inhibits different strains of EV-D68, EV-A71 and CVB3 with EC50 values in the nanomolar range and a cellular selectivity index of over 500.
UAWJ172 inhibits viral replication in a dose-response manner in neuronal cell line SH-SY5Y with IC50 of 0.03 uM.
UAWJ172 inhibits EV-D68 US/MO/14-18947 virus with an EC50 value of 0.07 ± 0.02 μM in CPE assay.

物理化学性质&存储条件

分子量	315.42
分子式	C17H25N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-cyclopropyl-N-(2-(dimethylamino)ethyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

参考文献

1. Yanmei Hu, et al. J Med Chem. 2021 Jun 24;64(12):8755-8774.

UAWJ172 (UAWJ 172)

生物&药学活性

物理化学性质&存储条件

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UAWJ172 (UAWJ 172)

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