UAB30 |CAS:205252-59-1 Probechem Biochemicals

Chemical Structure : UAB30

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UAB30 (9cUAB30)

货号: PC-35622Not For Human Use, Lab Use Only.

UAB30 (9cUAB30) is a novel synthetic rexinoid that binds selectively to the retinoid X receptor (RXR) leading to activation of genes involved in induction of differentiation and apoptosis.

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生物&药学活性

UAB30 (9cUAB30) is a novel synthetic rexinoid that binds selectively to the retinoid X receptor (RXR) leading to activation of genes involved in induction of differentiation and apoptosis.
UAB30 decreases cellular proliferation, invasion and migration, cell-cycle arrest, and increases apoptosis in xenograft tumor growth in neuroblastoma.
UAB30 prevents N-methyl-N-nitrosourea induced mammary cancers in rats without signs of toxicity.

物理化学性质&存储条件

分子量	294.394
分子式	C20H22O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4,6-Octatrienoic acid, 8-(3,4-dihydro-1(2H)-naphthalenylidene)-3,7-dimethyl-, (all-E)-

参考文献

1. Atigadda VR, et al. J Med Chem. 2003 Aug 14;46(17):3766-9.

2. Hansen NJ, et al. Int J Oncol. 2007 Mar;30(3):641-50.

3. Vedell PT, et al. Mol Pharmacol. 2013 Mar;83(3):698-708.

4. Waters AM, et al. Mol Cancer Ther. 2016 May;15(5):911-21.

UAB30 (9cUAB30)

生物&药学活性

物理化学性质&存储条件

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UAB30 (9cUAB30)

生物&药学活性

物理化学性质&存储条件

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