U18666A | NPC1 inhibitor | Probechem Biochemicals

Chemical Structure : U18666A

CAS No.: 3039-71-2

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U18666A (U 18666A)

货号: PC-49197Not For Human Use, Lab Use Only.

U18666A is a cationic sterol that blocks the movement of cholesterol out of lysosomes and also inhibits Ebola virus infections, targets niemann-Pick C1 (NPC1) which exports cholesterol derived from receptor-mediated uptake of LDL, and mediates cellular entry of Ebola virus.

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10 mg	￥1580	In stock
25 mg	￥2880	In stock
50 mg	￥4980	In stock
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200 mg		Get quote
1 g		Get quote

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生物&药学活性

U18666A is a cationic sterol that blocks the movement of cholesterol out of lysosomes and also inhibits Ebola virus infections, inhibits the vesicular trafficking protein Niemann-Pick C1 (NPC1) which exports cholesterol derived from receptor-mediated uptake of LDL, and mediates cellular entry of Ebola virus.

物理化学性质&存储条件

分子量	424.066
分子式	C25H42ClNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3beta)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride

参考文献

1. Bierkamper GG, et al. Brain Res. 1978 Jul 14;150(2):343-51.

2. Feiran Lu, et al. Elife. 2015 Dec 8;4:e12177.

3. Patel SC, et al. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1657-62.

4. Shoemaker CJ, et al. PLoS One. 2013;8(2):e56265.

U18666A (U 18666A)

生物&药学活性

物理化学性质&存储条件

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U18666A (U 18666A)

生物&药学活性

物理化学性质&存储条件

参考文献

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