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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MEK (MAP2K)-U0126
U0126

Chemical Structure : U0126

CAS No.: 1173097-76-1

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U0126 (U0126-EtOH;U 0126;U-0126)

货号: PC-42845Not For Human Use, Lab Use Only.

U0126 (U0126-EtOH) is a potent, selective MEK (MAP2K) inhibitor with IC50 of 70 nM and 60 nM for MEK1 and MEK2, suppresses AP-1-mediated gene activation in transient transfection assays with IC50 of 0.96 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

U0126 (U0126-EtOH) is a potent, selective MEK (MAP2K) inhibitor with IC50 of 70 nM and 60 nM for MEK1 and MEK2, suppresses AP-1-mediated gene activation in transient transfection assays with IC50 of 0.96 uM.
U0126 shows little to no effect on the kinase activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2, or Cdk4.
U0126 inhibits T cell proliferation in response to antigenic stimulation or cross-linked anti-CD3 plus anti-CD28 Abs, but has no effect on IL-2-induced proliferation.
U0126 reduces tumor size of tumor xenografts in nude mice.

物理化学性质&存储条件

分子量 426.5583
分子式 C20H22N6OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 49 mg/mL
Chemical Name/SMILES

Butanedinitrile, 2,3-bis[amino[(2-aminophenyl)thio]methylene]-, compd. with ethanol (1:1)

参考文献

1. Favata MF, et al. J Biol Chem. 1998 Jul 17;273(29):18623-32.

2. DeSilva DR, et al. J Immunol. 1998 May 1;160(9):4175-81.

3. Bessard A, et al. Oncogene. 2008 Sep 11;27(40):5315-25.

4. Duncia JV, et al. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2839-44.

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