Tyk2-IN-30 |CAS:1334407-95-2 Probechem Biochemicals

Chemical Structure : Tyk2-IN-30

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Tyk2-IN-30

货号: PC-63072Not For Human Use, Lab Use Only.

TYK2-IN-30 is a potent, selective and orally active Tyk2 inhibitor with Ki of 0.7 nM, exhibits excellent selectivity (35-fold for JAK1 and 83-fold for JAK3).

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生物&药学活性

TYK2-IN-30 is a potent, selective and orally active Tyk2 inhibitor with Ki of 0.7 nM, exhibits excellent selectivity (35-fold for JAK1 and 83-fold for JAK3).
TYK2-IN-30 potently inhibits IL-23 pathway in cells with EC50 of 66 nM, and has good pharmacokinetic properties.
TYK2-IN-30 demonstrates dose-dependent reduction of IL-17 production in a PK/PD model as well as in an imiquimod-induced psoriasis model.

物理化学性质&存储条件

分子量	396.235
分子式	C18H11Cl2N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-dichloro-4-(4-((6-methylpyrimidin-4-yl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)benzonitrile

参考文献

1. Liang J, et al. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4370-4376.

Tyk2-IN-30

生物&药学活性

物理化学性质&存储条件

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Tyk2-IN-30

生物&药学活性

物理化学性质&存储条件

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