Tuvusertib | ATR inhibitor | Probechem Biochemicals

Chemical Structure : Tuvusertib

CAS No.: 1613200-51-3

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Tuvusertib (M1774, M 1774)

货号: PC-21858Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

Tuvusertib (M1774) is a potent, selective, orally bioavailable ATR protein kinase inhibitor, shows anticancer activity against cance cell with expression the ATR inhibition sensitizing mixed lineage leukemia fusion protein.
Tuvusertib (M1774) shows antitumor activity as monotherapy in preclinical models with DDR pathway gene mutations, including an ATM mut nonsmall-cell lung cancer (NSCLC) xenograft model and an ARID1A mut gastric cancer xenograft model.
Tuvusertib (M1774) also shows antitumor activity as monotherapy and in combination with the PARP inhibitor niraparib in xenograft models of BRCA mut high-grade serous ovarian cancer.

物理化学性质&存储条件

分子量	370.32
分子式	C16H12F2N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Amino-6-fluoro-N-[5-fluoro-4-(1-methyl-1H-imidazol-5-yl)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

参考文献

1. Timothy A. Yap, et al. Journal of Clinical Oncology
Volume 39, Number 15_suppl. May 28, 2021

Tuvusertib (M1774, M 1774)

生物&药学活性

物理化学性质&存储条件

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Tuvusertib (M1774, M 1774)

生物&药学活性

物理化学性质&存储条件

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