Tuvatexib

Chemical Structure : Tuvatexib

CAS No.: 2055404-90-3

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货号: PC-35768Not For Human Use, Lab Use Only.

Tuvatexib is a potent, selective small molecule modulator of Hexokinase 2 (HK2) interaction with the mitochondria, selectively dissociates HK2 from VDAC1 in vitro with IC50 of 92 nM.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
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100 mg		Get quote

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生物&药学活性

Tuvatexib is a potent, selective small molecule modulator of Hexokinase 2 (HK2) interaction with the mitochondria, selectively dissociates HK2 from VDAC1 in vitro with IC50 of 92 nM.
Tuvatexib does not affect the VDAC1/HK1 complex.
Tuvatexib dose-dependent reduces mitochondrial-bound HK2 levels in human skin SCC A431 cells with IC50 of 0.8 uM, reduces glycolysis and triggers apoptosis in cancer cells, without affecting hexokinase 1-expressing normal cells.
Tuvatexib demonstrates anti-cancer activity in UVB-damaged skin model in SKH-1 mice.

物理化学性质&存储条件

分子量	337.419
分子式	C21H23NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Quinolin-8-yl (Z)-2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate

参考文献

1. Behar V, et al. J Invest Dermatol. 2018 Jun 14. pii: S0022-202X(18)32056-6.

2. Goldin N, et al. Oncogene. 2008 Aug 7;27(34):4636-43.

3. Krasnov GS, et al. Expert Opin Ther Targets. 2013 Oct;17(10):1221-33.

4. PCT Int. Appl. (2018), WO 2018083705 A1 20180511.

Tuvatexib

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物理化学性质&存储条件

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Tuvatexib

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