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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-Tulrampator
Tulrampator

Chemical Structure : Tulrampator

CAS No.: 1038984-31-4

Tulrampator (S 47445;CX 1632)

货号: PC-61726Not For Human Use, Lab Use Only.

Tulrampator (S 47445, CX 1632) is a potent, selective, positive allosteric modulator of AMPA receptor (AMPAR) with EC50 of 2.5-5.4 uM for different AMPA receptors subtypes (GluA1/2/4 flip and flop variants).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Tulrampator (S 47445, CX 1632) is a potent, selective, positive allosteric modulator of AMPA receptor (AMPAR) with EC50 of 2.5-5.4 uM for different AMPA receptors subtypes (GluA1/2/4 flip and flop variants).
Tulrampator exhibits procognitive and potential neuroprotective properties in vivo.

物理化学性质&存储条件

分子量 380.379
分子式 C20H17FN4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3H-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione

参考文献

1. Calabrese F, et al. Pharmacol Res. 2017 Jul;121:59-69.

2. Giralt A, et al. Neuropharmacology. 2017 Sep 1;123:395-409.

3. Bretin S, et al. PLoS One. 2017 Sep 8;12(9):e0184429.

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