Tubacin |CAS:537049-40-4 Probechem Biochemicals

Chemical Structure : Tubacin

CAS No.: 537049-40-4

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Tubacin

货号: PC-43533Not For Human Use, Lab Use Only.

Tubacin is a potent, selective inhibitor of class II histone deacetylase 6 (HDAC6) with IC50 of 4 nM, displays> 300-fold selectivity against all other HDAC isoforms.

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10 mg	￥3580	In stock
25 mg	￥5780	In stock
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生物&药学活性

Tubacin is a potent, selective inhibitor of class II histone deacetylase 6 (HDAC6) with IC50 of 4 nM, displays> 300-fold selectivity against all other HDAC isoforms.
Tubacin induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures, inhibits proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.
Tubacin also suppresses proliferation and induces apoptosis of AML cells.

物理化学性质&存储条件

分子量	721.861
分子式	C41H43N3O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Octanediamide, N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-, rel-

参考文献

1. Haggarty SJ, et al. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94.

2. Butler KV, et al. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.

3. Saji S, et al. Oncogene. 2005 Jun 30;24(28):4531-9.

4. Rao R, et al. Blood. 2008 Sep 1;112(5):1886-93.

Tubacin

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