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首页-小分子抑制剂&激动剂-Others-Other Targets-Tryptolinamide
Tryptolinamide

Chemical Structure : Tryptolinamide

CAS No.: 260798-40-1

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Tryptolinamide (TLAM)

货号: PC-49511Not For Human Use, Lab Use Only.

Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive and F6P-competitive manner (Ki=5.0 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive and F6P-competitive manner (Ki=5.0 uM).
    TLAM attenuates 2DG toxicity and modulates cellular metabolism in cancer cells.
    TLAM activates mitochondrial respiration via the AMPK/fatty-acid oxidation pathway.
    TLAM inhibits the enzymatic activity of all PFK1 isoforms (PFKM, PFKP and PFKL) but not PFK2 (PFKFB3).
    TLAM ameliorate the defective phenotypes of iPSCs derived from patients with mitochondrial disease by inhibiting PFK1.

    物理化学性质&存储条件

    分子量 404.39
    分子式 C21H19F3N2O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-2-carbonyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

    参考文献

    1. Kobayashi H, et al. Nat Chem Biol. 2021 Mar;17(3):335-343.

    2. Kobayashi H, et al. Cancer Sci. 2023 Jan 5. doi: 10.1111/cas.15713.

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