Trovafloxacin

Chemical Structure : Trovafloxacin

CAS No.: 147059-72-1

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货号: PC-21765Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Trovafloxacin is a broad-spectrum quinolone antibiotic, blocks the DNA gyrase and topoisomerase IV activity, also is a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with IC50 of 4 uM for PANX1 inward current.
Trovafloxacin does not inhibit connexin 43 gap junction or PANX2.
Trovafloxacin induces apoptosis and increases leakage of lactate dehydrogenase (LDH) in HepG2 cells, increases expression of early NF-κB-related factors A20 and IκBα.
Trovafloxacin is equally active against both penicillin-susceptible and -resistant pneumococci, with MICs of 0.06-0.25 mg/mL.

物理化学性质&存储条件

分子量	416.36
分子式	C20H15F3N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

参考文献

1. Poon IK, et al. Nature. 2014 Mar 20;507(7492):329-34.

2. Gootz TD, et al. Antimicrob Agents Chemother. 1996 Dec;40(12):2691-7.

Trovafloxacin

生物&药学活性

物理化学性质&存储条件

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Trovafloxacin

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