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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-Trotabresib
Trotabresib

Chemical Structure : Trotabresib

CAS No.: 1706738-98-8

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Trotabresib (CC-90010, CC90010, QC5487)

货号: PC-38040Not For Human Use, Lab Use Only.

Trotabresib (CC90010) is a reversible and orally active BET bromodomain inhibitor, shows significant antiproliferative activity in glioblastoma cells and patient-derived xenograft models as monotherapy and in combination with temozolomide (TMZ).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Trotabresib (CC90010) is a reversible and orally active BET bromodomain inhibitor, shows significant antiproliferative activity in glioblastoma cells and patient-derived xenograft models as monotherapy and in combination with temozolomide (TMZ).

物理化学性质&存储条件

分子量 383.462
分子式 C21H21NO4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1(2H)-Isoquinolinone, 4-(2-(cyclopropylmethoxy)-5-(methylsulfonyl)phenyl)-2-methyl-

参考文献

1. Moreno V, et al. Ann Oncol. 2020 Jun;31(6):780-788.

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