Tropisetron | 5-HT3R antagonist | Probechem Biochemicals

Chemical Structure : Tropisetron

CAS No.: 89565-68-4

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Tropisetron (SDZ-ICS-930)

货号: PC-26558Not For Human Use, Lab Use Only.

Tropisetron (SDZ-ICS-930) is a potent, orally active 5-HT3R antagonist (Ki=5.3 nM), also is a potent and selective α7 nicotinic partial agonist (EC50=1.3 uM).

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100 mg	￥1180	In stock
500 mg	￥2180	In stock
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生物&药学活性

Tropisetron (SDZ-ICS-930) is a potent, orally active 5-HT3R antagonist (Ki=5.3 nM), also is a potent and selective α7 nicotinic partial agonist (EC50=1.3 uM).
Tropisetron prevents phosphorylation and activation of the p38 MAPK.
Tropisetron inhibits both IL-2 gene transcription and IL-2 synthesis in stimulated T cells.
Tropisetron inhibits the binding to DNA and the transcriptional activity of NFAT and AP-1.
Tropisetron shows anti-inflammatory and antiemetic.

物理化学性质&存储条件

分子量	284.36
分子式	C17H20N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	rel-(1R,3r,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 1H-indole-3-carboxylate

参考文献

1. Macor JE, et al. Bioorg Med Chem Lett. 2001 Feb 12;11(3):319-21.

2. Vega Lde L, et al. Biochem Pharmacol. 2005 Aug 1;70(3):369-80.

Tropisetron (SDZ-ICS-930)

生物&药学活性

物理化学性质&存储条件

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Tropisetron (SDZ-ICS-930)

生物&药学活性

物理化学性质&存储条件

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