TrmD-IN-4

Chemical Structure : TrmD-IN-4

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货号: PC-27825Not For Human Use, Lab Use Only.

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生物&药学活性

TrmD-IN-4 is a potent, covalent inhibitor of bacterial tRNA (m1G37) methyltransferase (TrmD) with IC50 of 4.43 uM, with minimal inhibition of human Trm5, shows selective growth inhibition in bacteria expressing TrmD.
TrmD-IN-4 displays potent activity against multiple Staphylococcus aureus strains, including a methicillin-sensitive strain (MSSA), methicillin-resistant strains (MRSA), and an enterotoxin producer strain (MIC = 1.56–6.25 μM) and moderate activity against additional Gram-negative organisms, including Haemophilus influenzae and Vibrio cholerae (MIC = 50 μM).

物理化学性质&存储条件

分子量	470.57
分子式	C28H30N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-6-((2-methyl-2-(3-((4-oxo-4-(o-tolyl)but-2-enamido)methyl)phenyl)propyl)amino)nicotinamide

参考文献

1. Masuda I, et al. ACS Med Chem Lett. 2026 Jun 10;17(8):1766-1779.

TrmD-IN-4

生物&药学活性

物理化学性质&存储条件

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TrmD-IN-4

生物&药学活性

物理化学性质&存储条件

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