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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-TrmD-IN-3
TrmD-IN-3

Chemical Structure : TrmD-IN-3

CAS No.:

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TrmD-IN-3

货号: PC-27824Not For Human Use, Lab Use Only.

TrmD-IN-3 is a potent, covalent inhibitor of bacterial tRNA (m1G37) methyltransferase (TrmD) with IC50 of 1.17 uM for E. coli TrmD, with minimal inhibition of human Trm5 (IC50=2.17 mM), shows selective growth inhibition in bacteria expressing TrmD.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TrmD-IN-3 is a potent, covalent inhibitor of bacterial tRNA (m1G37) methyltransferase (TrmD) with IC50 of 1.17 uM for E. coli TrmD, with minimal inhibition of human Trm5 (IC50=2.17 mM), shows selective growth inhibition in bacteria expressing TrmD.

物理化学性质&存储条件

分子量 456.55
分子式 C27H28N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-6-((2-methyl-2-(3-((4-oxo-4-phenylbut-2-enamido)methyl)phenyl)propyl)amino)nicotinamide

参考文献

1. Masuda I, et al. ACS Med Chem Lett. 2026 Jun 10;17(8):1766-1779.

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