Chemical Structure : TrmD-IN-2
货号: PC-27823Not For Human Use, Lab Use Only.
TrmD-IN-2 is a potent, covalent inhibitor of bacterial tRNA (m1G37) methyltransferase (TrmD) with IC50 of 0.85 uM for E. coli TrmD, with minimal inhibition of human Trm5 (IC50=1.88 mM), shows selective growth inhibition in bacteria expressing TrmD.
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TrmD-IN-2 is a potent, covalent inhibitor of bacterial tRNA (m1G37) methyltransferase (TrmD) with IC50 of 0.85 uM for E. coli TrmD, with minimal inhibition of human Trm5 (IC50=1.88 mM), shows selective growth inhibition in bacteria expressing TrmD.
| 分子量 | 470.57 | |
| 分子式 | C28H30N4O3 | |
| 外观性状 | Solid | |
| 储存条件 |
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| Solubility |
10 mM in DMSO |
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1. Masuda I, et al. ACS Med Chem Lett. 2026 Jun 10;17(8):1766-1779.
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