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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-TrmD-IN-1
TrmD-IN-1

Chemical Structure : TrmD-IN-1

CAS No.: 3132496-73-9

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TrmD-IN-1

货号: PC-27822Not For Human Use, Lab Use Only.

TrmD-IN-1 (Compound 8h) is a specific small molecule inhibitor of S. aureus tRNA (m1G37) methyltransferase (TrmD) with KD of 2.48 uM in FP-assays, does not affect Trm5, shows antimicrobial effects at low micromolar concentrations.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TrmD-IN-1 (Compound 8h) is a specific small molecule inhibitor of S. aureus tRNA (m1G37) methyltransferase (TrmD) with KD of 2.48 uM in FP-assays, does not affect Trm5, shows antimicrobial effects at low micromolar concentrations.

物理化学性质&存储条件

分子量 287.29
分子式 C11H13N9O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2-(4-(4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-1,2,3-triazol-1-yl)ethyl)guanidine

参考文献

1. Hübner AF, et al. J Med Chem. 2025 Dec 25;68(24):26246-26262.

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