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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Antifolate-Trimetrexate
Trimetrexate

Chemical Structure : Trimetrexate

CAS No.: 52128-35-5

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Trimetrexate (CI-898, CI898, NSC249008)

货号: PC-42556Not For Human Use, Lab Use Only.

Trimetrexate (CI-898, NSC249008) is a quinazoline derivative and antifolate agent that fuctions as a dihydrofolate reductase (DHFR) inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Trimetrexate (CI-898, NSC249008) is a quinazoline derivative and antifolate agent that fuctions as a dihydrofolate reductase (DHFR) inhibitor.
Trimetrexate shows activity against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate.

物理化学性质&存储条件

分子量 369.4176
分子式 C19H23N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-

参考文献

1. Weir EC, et al. Cancer Res. 1982 May;42(5):1696-702.

2. Diddens H, et al. Cancer Res. 1983 Nov;43(11):5286-92.

3. Elslager EF, et al. J Med Chem. 1983 Dec;26(12):1753-60.

4. Wong BK, et al. Drug Metab Dispos. 1990 Nov-Dec;18(6):980-6.

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