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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-RAR/RXR-Trifarotene
Trifarotene

Chemical Structure : Trifarotene

CAS No.: 895542-09-3

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Trifarotene (CD5789;CD-5789)

货号: PC-35171Not For Human Use, Lab Use Only.

Trifarotene (CD5789, CD-5789) is a potent and selective RARγ agonist with EC50 of 7.7 nM, 500- and 125-fold selectivity over RARα and RARβ.

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25 mg ￥1980 In stock
100 mg ￥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Trifarotene (CD5789, CD-5789) is a potent and selective RARγ agonist with EC50 of 7.7 nM, 500- and 125-fold selectivity over RARα and RARβ.
Trifarotene (CD5789, CD-5789) demonstrates potential for the treatment of acne in clinical trials.

物理化学性质&存储条件

分子量 459.586
分子式 C29H33NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3''-(tert-butyl)-4'-(2-hydroxyethoxy)-4''-(pyrrolidin-1-yl)-[1,1':3',1''-terphenyl]-4-carboxylic acid

参考文献

1. Thoreau E, et al. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1736-1741.

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