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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-Akt-Triciribine
Triciribine

Chemical Structure : Triciribine

CAS No.: 35943-35-2

Triciribine (API-2, NSC 154020, TCN)

货号: PC-23340Not For Human Use, Lab Use Only.

Triciribine is a purine analog and DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively, selectively inhibits the phosphorylation and activation of all three Akt isoforms.

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5 mg ¥780 In stock
10 mg ¥1180 In stock
25 mg ¥1980 In stock
50 mg ¥2980 In stock
100 mg ¥4580 In stock

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Triciribine is a purine analog and DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively, selectively inhibits the phosphorylation and activation of all three Akt isoforms.

物理化学性质&存储条件

分子量 320.31
分子式 C13H16N6O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R,3R,4S,5R)-2-(3-Amino-5-methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

参考文献

1. Dieterle A, et al. Int J Cancer. 2009 Aug 15;125(4):932-41.

2. Kucera LS, et al. AIDS Res Hum Retroviruses. 1993 Apr;9(4):307-14.

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