Trichostatin A (TSA)

Chemical Structure : Trichostatin A

CAS No.: 58880-19-6

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货号: PC-24323Not For Human Use, Lab Use Only.

Trichostatin A (TSA) is a potent and specific, irreversible inhibitor of class I/II HDACs with IC50 of 1.8 nM for HDAC.

规格	价格	库存
2 mg	￥880	In stock
5 mg	￥1480	In stock
10 mg	￥2580	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

Trichostatin A (TSA) is a potent and specific, irreversible inhibitor of class I/II HDACs with IC50 of 1.8 nM for HDAC.
Trichostatin A potently inhibits purified histone deacetylase from wild-type FM3A cells with Ki of 3.4 nM.
Trichostatin A markedly prolongs the in vivo half-life of the labile acetyl groups on histones in mouse mammary gland tumor cells, FM3A.
Trichostatin A inhibited proliferation of eight breast carcinoma cell lines with IC50 of 26.4-308.1 nM.
Trichostatin A exhibits antitumor efficacy and toxicity in vivo in a carcinogen-induced rat mammary cancer model.

物理化学性质&存储条件

分子量	302.37
分子式	C17H22N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R,2E,4E)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide

参考文献

1. Yoshida M, et al. J Biol Chem. 1990 Oct 5;265(28):17174-9.

2. Yoshida M, et al. J Antibiot (Tokyo). 1990 Sep;43(9):1101-6.

3. Futamura M, et al. Oncogene. 1995 Mar 16;10(6):1119-23.

4. Vigushin DM et al. Clin Cancer Res. 2001 Apr;7(4):971-6.