Triacsin C | ACSL inhibitor | Probechem Biochemicals

Chemical Structure : Triacsin C

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Triacsin C (WS 1228A, FR 900190)

货号: PC-22161Not For Human Use, Lab Use Only.

Triacsin C (WS 1228A) is an inhibitor of long fatty acid acyl-CoA synthetase (ACSL) with IC50 of 6.3 μM in Raji cells, inhibits TAG accumulation into lipid droplets (LD).

规格	价格	库存	数量
500 ug		Get quote
1 mg		Get quote
5 mg		Get quote
10 mg		Get quote

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生物&药学活性

Triacsin C (WS 1228A) is an inhibitor of long fatty acid acyl-CoA synthetase (ACSL) with IC50 of 6.3 μM in Raji cells, inhibits TAG accumulation into lipid droplets (LD).
Triacsin C has been shown to interfere with lipid metabolism by inhibiting the de novo synthesis of triglycerides, diglycerides, and cholesterol esters.
Triacsin C also act as a hypotensive vasodilator, modulating endothelial nitric oxide synthase repalmitoylation by limiting palmitoyl CoA availability.
Triacsin C inhibits pancreatic β-cell function by suppressing the mobilization of intracellular calcium.

物理化学性质&存储条件

分子量	207.28
分子式	C11H17N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N'-((1E,2E,4E,7E)-undeca-2,4,7-trien-1-ylidene)nitrous hydrazide

参考文献

1. Kim Y, et al. Eur J Med Chem. 2012 Apr;50:311-8.

2. Dechandt CRP, et al. J Bioenerg Biomembr. 2017 Oct;49(5):399-411.

3. Matsuda D, et al. J Antibiot (Tokyo). 2008 May;61(5):318-21.

Triacsin C (WS 1228A, FR 900190)

生物&药学活性

物理化学性质&存储条件

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Triacsin C (WS 1228A, FR 900190)

生物&药学活性

物理化学性质&存储条件

参考文献

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