Trazodone | Antidepressant | Probechem Biochemicals

Chemical Structure : Trazodone

CAS No.: 19794-93-5

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Trazodone (AF-1161)

货号: PC-26777Not For Human Use, Lab Use Only.

Trazodone (AF-1161) is an antidepressant that inhibits reuptake of serotonin, causes adrenoreceptor subsensitivity, acts as a 5HT2a receptor antagonist and induces significant changes in 5-HT presynaptic receptor adrenoreceptors, also significantly blocks histamine (H1) and alpha1-adrenergic receptors.

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50 mg	￥380	In stock
100 mg	￥580	In stock
250 mg	￥980	In stock
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生物&药学活性

物理化学性质&存储条件

分子量	371.86
分子式	C19H22ClN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

参考文献

1. agiolini A, et, al. Rediscovering trazodone for the treatment of major depressive disorder. CNS Drugs. 2012 Dec;26(12):1033-49.

2. Ghanbari, R., et al., (2010). Sustained administration of trazodone enhances serotonergic neurotransmission: in vivo electrophysiological study in the rat brain. The Journal of pharmacology and experimental therapeutics, 335(1), 197–206.

Trazodone (AF-1161)

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Trazodone (AF-1161)

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