Traxoprodil mesylate |CAS:188591-67-5 Probechem Biochemicals

Chemical Structure : Traxoprodil mesylate

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Traxoprodil mesylate (CP-101606 mesylate)

货号: PC-61515Not For Human Use, Lab Use Only.

Traxoprodil mesylate (CP 101606 mesylate) is a potent, selective N-methyl-D-aspartate (NMDA) antagonist with selectivity for the NR2B subunit.

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生物&药学活性

Traxoprodil mesylate (CP 101606 mesylate) is a potent, selective N-methyl-D-aspartate (NMDA) antagonist with selectivity for the NR2B subunit.
Traxoprodil mesylate potently protects cultured hippocampal neurons from glutamate toxicity (IC50=10 nM), dramatically reduces both the open dwell-time and frequency of channel opening of NR1/NR2B-containing receptors, but only modestly inhibits NR1/NR2A and NR1/NR2C channel activity.
Traxoprodil mesylate exhibits neuroprotective, analgesic, and anti-Parkinsonian effects in animal studies.

物理化学性质&存储条件

分子量	423.524
分子式	C21H29NO6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol mesylate

参考文献

1. Chenard BL, et al. J Med Chem. 1995 Aug 4;38(16):3138-45.

2. Taniguchi K, et al. Br J Pharmacol. 1997 Nov;122(5):809-12.

3. Brimecombe JC, et al. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):11019-24.

4. Guscott MR, et al. Eur J Pharmacol. 2003 Aug 29;476(3):193-9.

Traxoprodil mesylate (CP-101606 mesylate)

生物&药学活性

物理化学性质&存储条件

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Traxoprodil mesylate (CP-101606 mesylate)

生物&药学活性

物理化学性质&存储条件

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