Transthyretin stabilizer M-23

Chemical Structure : Transthyretin stabilizer M-23

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货号: PC-49422Not For Human Use, Lab Use Only.

Transthyretin stabilizer M-23 is a potent transthyretin (TTR) stabilizer with binding Kd of 6 nM (WT-TTR), enhances TTR tetramer stability both in vitro and in whole serume.

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50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Transthyretin stabilizer M-23 is a potent transthyretin (TTR) stabilizer with binding Kd of 6 nM (WT-TTR), enhances TTR tetramer stability both in vitro and in whole serume.
M-23 effectively prevented TTR amyloid formation at acidic pH, stabilizes the TTR dimer-dimer interface.
M-23 strongly binds to TTR in human plasma, exhibiting a higher TTR stabilizing activity than the reference molecule tolcapone.

物理化学性质&存储条件

分子量	293.206
分子式	C13H8FNO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3,4-Dihydroxy-5-nitrophenyl)-(3-fluoro-5-hydroxyphenyl)methanone

参考文献

1. Pinheiro F, et al. J Med Chem. 2022 Oct 28. doi: 10.1021/acs.jmedchem.2c01195.