Tranilast |Cas:53902-12-8 Buy Tranilast from ProbeChem, Global Biochemicals Supplier

Chemical Structure : Tranilast

CAS No.: 53902-12-8

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Tranilast (MK-341;SB-252218)

货号: PC-70135Not For Human Use, Lab Use Only.

规格	价格	库存
50 mg	￥1280	In stock
100 mg	￥1980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Tranilast (MK-341) is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells.
Tranilast (MK-341) is an inhibitor of calcium-permeable TRPV2 channel, inhibits insulin increased calcium entry in beta-cells.
Tranilast inhibits endotoxin-induced PGE2 (IC50=1-20 uM), thromboxane B2 (IC50= 10-50 uM), TGF-β1 (IC50=100-200 uM), and IL-8 (IC50=100 uM) formation, but has no effect on TNF-α.
Tranilast also inhibits VEGF-induced angiogenetic activities.
Tranilast also is an inhibitor of the transcription factor Forkhead box O-1 (FoxO-1).

物理化学性质&存储条件

分子量	327.33
分子式	C18H17NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzoic acid, 2-[[3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl]amino]- (9CI)

参考文献

1. Capper EA, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1061-9.

2. Ikai K, et al. Biochem Pharmacol. 1989 Aug 15;38(16):2673-6.

3. Koyama S, et al. Br J Pharmacol. 1999 May;127(2):537-45.

Tranilast (MK-341;SB-252218)

生物&药学活性

物理化学性质&存储条件

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Tranilast (MK-341;SB-252218)

生物&药学活性

物理化学性质&存储条件

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