Trametinib DMSO solvate |CAS:1187431-43-1 Probechem Biochemicals

Chemical Structure : Trametinib DMSO solvate

CAS No.: 1187431-43-1

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货号: PC-42775Not For Human Use, Lab Use Only.

A potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.

规格	价格	库存	数量
50 mg	￥640	In stock
100 mg	￥952.0	In stock

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生物&药学活性

A potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM; exhibits no inhibition on the kinase activities of c-Raf, B-Raf, ERK1/2.

Skin Cancer

Approved

分子量	693.5283
分子式	C28H29FIN5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 69 mg/mL (Need ultrasonic)
Chemical Name/SMILES	N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide compound with (methylsulfinyl)methane (1:1)

1. Gilmartin AG, et al. Clin Cancer Res. 2011 Mar 1;17(5):989-1000.

2. Flaherty KT, et al. N Engl J Med. 2012 Nov 1;367(18):1694-703.

3. Yamaguchi T, et al. Int J Oncol, 2011, 39(1), 23-31.