Tpl2/MAP3K8 inhibitor 33 | Tpl2/MAP3K8 inhibitor | Probechem Biochemicals

Chemical Structure : Tpl2/MAP3K8 inhibitor 33

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Tpl2/MAP3K8 inhibitor 33 (COT kinase inhibitor 33)

货号: PC-22734Not For Human Use, Lab Use Only.

Tpl2/MAP3K8 inhibitor 33 is a potent, selective inhibitor of cancer osaka thyroid (COT) kinase (Tpl2, MAP3K8) with IC50 of 4 nM.

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生物&药学活性

Tpl2/MAP3K8 inhibitor 33 is a potent, selective inhibitor of cancer osaka thyroid (COT) kinase (Tpl2, MAP3K8) with IC50 of 4 nM.
Tpl2/MAP3K8 inhibitor 33 inhibits pERK and TNFα production in PBMCs with IC50 of 30 nM for both.

物理化学性质&存储条件

分子量	516.61
分子式	C30H28N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(1-morpholinopropan-2-yl)-6-(8-(pyridin-4-yl)-1H-imidazo[4,5-c][1,7]naphthyridin-1-yl)quinolin-2-amine

参考文献

1. Ralf Glatthar, et al. J Med Chem. 2016 Aug 25;59(16):7544-60.

Tpl2/MAP3K8 inhibitor 33 (COT kinase inhibitor 33)

生物&药学活性

物理化学性质&存储条件

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Tpl2/MAP3K8 inhibitor 33 (COT kinase inhibitor 33)

生物&药学活性

物理化学性质&存储条件

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