Tpl2/MAP3K8 inhibitor 32 | Tpl2/MAP3K8 inhibitor | Probechem Biochemicals

Chemical Structure : Tpl2/MAP3K8 inhibitor 32

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Tpl2/MAP3K8 inhibitor 32 (COT kinase inhibitor 32)

货号: PC-22733Not For Human Use, Lab Use Only.

Tpl2/MAP3K8 inhibitor 32 is a potent, selective inhibitor of cancer osaka thyroid (COT) kinase (Tpl2, MAP3K8) with IC50 of 6 nM.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Tpl2/MAP3K8 inhibitor 32 is a potent, selective inhibitor of cancer osaka thyroid (COT) kinase (Tpl2, MAP3K8) with IC50 of 6 nM.
Tpl2/MAP3K8 inhibitor 32 inhibits pERK and TNFα production in PBMCs with IC50 of 60 nM for both.
Tpl2/MAP3K8 inhibitor 32 demonstrates potent inhibition of the formation of the pro-inflammatory cytokine interleukin-1β (IC50: 0.2 μM) in uric-acid, stimulated macrophages.
Tpl2/MAP3K8 inhibitor 32 (5-15 mg/kg) shows a clear amelioration of inflammatory events in the dog uric acid-induced synovitis model.

物理化学性质&存储条件

分子量	516.61
分子式	C30H28N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-morpholinopropan-2-yl)-6-(8-(pyridin-4-yl)-1H-imidazo[4,5-c][1,7]naphthyridin-1-yl)quinolin-2-amine

参考文献

1. Ralf Glatthar, et al. J Med Chem. 2016 Aug 25;59(16):7544-60.

Tpl2/MAP3K8 inhibitor 32 (COT kinase inhibitor 32)

生物&药学活性

物理化学性质&存储条件

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Tpl2/MAP3K8 inhibitor 32 (COT kinase inhibitor 32)

生物&药学活性

物理化学性质&存储条件

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