Tpl2-1 | Tpl2/MAP3K8 inhibitor | Probechem Biochemicals

Chemical Structure : Tpl2-1

CAS No.: 871307-18-5

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Tpl2-1 (Tpl2 kinase inhibitor 1, Cot/MAP3K8 inhibitor, Tpl2-IN-2p)

货号: PC-70030Not For Human Use, Lab Use Only.

Tpl2-1 is a potent, selective, reversible and ATP-competitive inhibitor of Tpl2 kinase (Cot/MAP3K8) with IC50 of 50 nM.

规格	价格	库存
1 mg	￥1580	In stock
5 mg	￥3980	In stock
10 mg	￥5980	In stock
25 mg		Get quote
50 mg		Get quote

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生物&药学活性

Tpl2-1 is a potent, selective, reversible and ATP-competitive inhibitor of Tpl2 kinase (Cot/MAP3K8) with IC50 of 50 nM.
Tpl2-1 dispalys significant selectivity over other related kinases (IC50= 5, >40, 110, 180, >400 and >400 uM for EGFR, MEK, MK2, p38, Src, and PKC, respectively).
Tpl2-1 inhibits LPS-induced TNF-α production both from primary human monocytes and in whole blood with IC50 of 0.7 and 8.5 uM, respectively;

物理化学性质&存储条件

分子量	404.83
分子式	C21H14ClFN6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((3-chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile

参考文献

1. Gavrin LK, et al. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92.

2. Lee WJ, et al. Neoplasia. 2013 Sep;15(9):1036-48.

3. Lee HW, et al. Mol Cancer Res. 2013 Nov;11(11):1375-86.

Tpl2-1 (Tpl2 kinase inhibitor 1, Cot/MAP3K8 inhibitor, Tpl2-IN-2p)

生物&药学活性

物理化学性质&存储条件

参考文献

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Tpl2-1 (Tpl2 kinase inhibitor 1, Cot/MAP3K8 inhibitor, Tpl2-IN-2p)

生物&药学活性

物理化学性质&存储条件

参考文献

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