Tovorafenib | pan-RAF inhibitor | Probechem Biochemicals

Chemical Structure : Tovorafenib

CAS No.: 1096708-71-2

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Tovorafenib (MLN2480, BIIB-024, TAK-580)

货号: PC-73449Not For Human Use, Lab Use Only.

Tovorafenib (MLN2480, TAK-580) is potent, selective, brain-penetrant RAF dimer antagonist, inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

Tovorafenib (MLN2480, TAK-580) is potent, selective, brain-penetrant RAF dimer antagonist, inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models.
MLN2480 can cross the blood–brain barrier and retard growth of BRAFV600E and KIAA1549:BRAF intracranial tumors in NCr-NU mice.
MLN2480 retarded the growth of both of both BRAFV600E and KIAA1549:BRAF-driven tumors and increased survival of the treated mice.
MLN2480 is an equipotent inhibitor of catalysis in BRAF monomers and dimers.

物理化学性质&存储条件

分子量	506.3
分子式	C17H12Cl2F3N7O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(1-(6-Amino-5-chloropyrimidine-4-carboxamido)ethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide

参考文献

1. Sun Y, et al. Neuro Oncol. 2017 Jun 1;19(6):774-785.

2. Gampa G, et al. J Pharmacol Exp Ther. 2019 Mar;368(3):446-461.

3. Suzuki R, et al. Int J Hematol. 2022 Feb;115(2):233-243.

4. Samatar AA, et al. Nat Rev Drug Discov. 2014; 13(12):928-942.

Tovorafenib (MLN2480, BIIB-024, TAK-580)

生物&药学活性

物理化学性质&存储条件

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Tovorafenib (MLN2480, BIIB-024, TAK-580)

生物&药学活性

物理化学性质&存储条件

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