Tosedostat |CAS:238750-77-1 Probechem Biochemicals

Chemical Structure : Tosedostat

CAS No.: 238750-77-1

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Tosedostat (CHR-2797;CHR2797)

货号: PC-70071Not For Human Use, Lab Use Only.

Tosedostat (CHR-2797, CHR2797) is a potent, orally bioavailable aminopeptidases inhibitor with IC50 of 150, 220 and 100 nM for PuSA, aminopeptidase N and leucine aminopeptidase, respectively.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5480	In stock
100 mg		Get quote

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生物&药学活性

Tosedostat (CHR-2797, CHR2797) is a potent, orally bioavailable aminopeptidases inhibitor with IC50 of 150, 220 and 100 nM for PuSA, aminopeptidase N and leucine aminopeptidase, respectively.
Tosedostat (CHR-2797) exerts antiproliferative effects against a range of tumor cell lines in vitro and in vivo and shows selectivity for transformed over nontransformed cells.
Tosedostat (CHR-2797) inhibits phosphorylation of mTOR substrates and reduces protein synthesis in HL-60 cells.

物理化学性质&存储条件

分子量	406.479
分子式	C21H30N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	cyclopentyl (S)-2-((R)-2-((S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methylpentanamido)-2-phenylacetate

参考文献

1. Krige D, et al. Cancer Res. 2008 Aug 15;68(16):6669-79.

2. Moore HE, et al. Mol Cancer Ther. 2009 Apr;8(4):762-70.

3. Reid AH, et al. Clin Cancer Res. 2009 Aug 1;15(15):4978-85.

Tosedostat (CHR-2797;CHR2797)

生物&药学活性

物理化学性质&存储条件

参考文献

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Tosedostat (CHR-2797;CHR2797)

生物&药学活性

物理化学性质&存储条件

参考文献

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