Topobexin | TOP2B inhibitor | Probechem Biochemicals

Chemical Structure : Topobexin

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Topobexin (Topoisomerase 2B obex inhibitor)

货号: PC-24768Not For Human Use, Lab Use Only.

Topobexin is a selective Topoisomerase IIβ (TOP2B) catalytic inhibitor with IC50 of 0.19 uM in DNA decatenation assays, 25-fold selective over TOP2A (IC50=4.8 uM).

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生物&药学活性

Topobexin is a selective Topoisomerase IIβ (TOP2B) catalytic inhibitor with IC50 of 0.19 uM in DNA decatenation assays, 25-fold selective over TOP2A (IC50=4.8 uM).
Topobexin binds to non-identical residues in the obex pocket. targets the TOP2B ATPase domain.
Topobexin protects cardiomyocytes in isolated rat neonatal ventricular cardiomyocytes (NVCM) against toxicity (LDH release) induced by daunorubicin (DAU).
Topobexin (1 uM) significantly reduced TOP2B-DNA CC in RADAR assays using HEK293F cells, with no effect on TOP2A-DNA CC.
Topobexin (10 mg/kg, i.v.) prevents anthracycline-induced cardiotoxicity in a rabbit model.

物理化学性质&存储条件

分子量	489.62
分子式	C29H35N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(2-(4-methylpiperazin-1-yl)ethoxy)-4-propyl-8-(1,2,3,4-tetrahydroquinoline-1-carbonyl)-2H-chromen-2-one

参考文献

1. Kubeš J, et al. Nat Commun. 2025 May 28;16(1):4928.

Topobexin (Topoisomerase 2B obex inhibitor)

生物&药学活性

物理化学性质&存储条件

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Topobexin (Topoisomerase 2B obex inhibitor)

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物理化学性质&存储条件

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