TopBP1 inhibitor 5D4

Chemical Structure : TopBP1 inhibitor 5D4

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货号: PC-21291Not For Human Use, Lab Use Only.

TopBP1 inhibitor 5D4 is a small-molecule inhibitor of TopBP1 (topoisomerase IIβ-binding protein 1), specifically targets the BRCT7/8 domains of TopBP1, blocks MYC activity by freeing MIZ1, a MYC inhibitor, from TopBP1.

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200 mg		Get quote

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生物&药学活性

TopBP1 inhibitor 5D4 is a small-molecule inhibitor of TopBP1 (topoisomerase IIβ-binding protein 1), specifically targets the BRCT7/8 domains of TopBP1, blocks MYC activity by freeing MIZ1, a MYC inhibitor, from TopBP1.
TopBP1 inhibitor 5D4 also inhibits Rad51 foci formation and synergize with inhibitors of PARP1/2 or PARP14.
TopBP1 (topoisomerase IIβ-binding protein 1) functions at the convergent point of Rb, PI3K/Akt, and p53 pathways, making it a promising cancer therapeutic target.

物理化学性质&存储条件

分子量	466.63
分子式	C30H34N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-methoxybenzyl)-1-(5-(1-methyl-3-(naphthalen-2-yl)-1H-pyrazol-5-yl)quinuclidin-2-yl)methanamine

参考文献

1. Fang-Tsyr Lin, et al. Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2307793120.