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首页-小分子抑制剂&激动剂-Tyrosine Kinase-BTK-Tolebrutinib
Tolebrutinib

Chemical Structure : Tolebrutinib

CAS No.: 1971920-73-6

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Tolebrutinib (PRN2246, SAR442168, BTK168)

货号: PC-38193Not For Human Use, Lab Use Only.

Tolebrutinib (PRN2246, SAR442168, BTK168) is a potent, selective oral brain-penetrant BTK inhibitor with IC50 of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.

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25 mg ￥2180 In stock
50 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Tolebrutinib (PRN2246, SAR442168, BTK168) is a potent, selective oral brain-penetrant BTK inhibitor with IC50 of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively.
Tolebrutinib demonstrates potential immunomodulatory and anti-inflammatory activities, reduced new active brain lesions on MRI in people with relapsing multiple sclerosis (MS) in clinical investigation.

物理化学性质&存储条件

分子量 455.518
分子式 C26H25N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-amino-3-(4-phenoxyphenyl)-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]imidazo[4,5-c]pyridin-2-one

参考文献

1. Dahl K, et al. J Labelled Comp Radiopharm. 2020 Sep;63(11):482-487.

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