Tolcapone |CAS:134308-13-7 Probechem Biochemicals

Chemical Structure : Tolcapone

CAS No.: 134308-13-7

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Tolcapone (Ro 40-7592)

货号: PC-45228Not For Human Use, Lab Use Only.

Tolcapone (Ro 40-7592) selective, potent and reversible nitrocatechol-type inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 700 nM.

规格	价格	库存
100 mg	￥1980	In stock
200 mg	￥2980	In stock
1 g		Get quote
5 g		Get quote

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生物&药学活性

Tolcapone (Ro 40-7592) selective, potent and reversible nitrocatechol-type inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 700 nM.
Tolcapone (Ro 40-7592) kills neuroblastoma (NB) cells in preclinical models by inhibition of COMT.
Tolcapone (Ro 40-7592) induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma.
Tolcapone (Ro 40-7592) also is a potent Transthyretin (TTR) aggregation inhibitor.

物理化学性质&存储条件

分子量	273.2408
分子式	C14H11NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-

参考文献

1. Maj J, et al. J Neural Transm Park Dis Dement Sect. 1990;2(2):101-12.

2. Maser T, et al. Cancer Med. 2017 Jun;6(6):1341-1352.

3. Sant'Anna R, et al. Nat Commun. 2016 Feb 23;7:10787.

Tolcapone (Ro 40-7592)

生物&药学活性

物理化学性质&存储条件

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Tolcapone (Ro 40-7592)

生物&药学活性

物理化学性质&存储条件

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