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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-SGLT-Tofogliflozin hydrate
Tofogliflozin hydrate

Chemical Structure : Tofogliflozin hydrate

CAS No.: 1201913-82-7

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Tofogliflozin hydrate (CSG452 hydrate, CSG-452 hydrate)

货号: PC-43518Not For Human Use, Lab Use Only.

Tofogliflozin (CSG-452) hydrate is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2680 In stock
50 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Tofogliflozin (CSG-452) hydrate is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.
Tofogliflozin (CSG-452) displays high selectivity over human SGLT2 versus human SGLT1, SGLT6, and sodium/myo-inositol transporter 1.
Tofogliflozin (CSG-452) increases renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats, also improves postprandial glucose excursion.
Tofogliflozin (CSG-452) reduces glycated hemoglobin and improved glucose tolerance in the oral glucose tolerance test in vivo.

物理化学性质&存储条件

分子量 404.45
分子式 C22H28O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Spiro[isobenzofuran-1(3H),2'-[2H]pyran]-3',4',5'-triol, 6-[(4-ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)-, hydrate (1:1), (1S,3'R,4'S,5'S,6'R)-

参考文献

1. Suzuki M, et al. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.

2. Ohtake Y, et al. J Med Chem. 2012 Sep 13;55(17):7828-40.

3. Nagata T, et al. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E414-23.

4. Nagata T, et al. Br J Pharmacol. 2013 Oct;170(3):519-31.

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