Tofogliflozin | SGLT2 inhibitor | Probechem Biochemicals

Chemical Structure : Tofogliflozin

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Tofogliflozin (CSG452, CSG-452)

货号: PC-44120Not For Human Use, Lab Use Only.

Tofogliflozin (CSG-452) is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.

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生物&药学活性

Tofogliflozin (CSG-452) is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.
Tofogliflozin displays high selectivity over human SGLT2 versus human SGLT1, SGLT6, and sodium/myo-inositol transporter 1.
Tofogliflozin increases renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats, also improves postprandial glucose excursion.
Tofogliflozin reduces glycated hemoglobin and improved glucose tolerance in the oral glucose tolerance test in vivo.

物理化学性质&存储条件

分子量	386.44
分子式	C22H26O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[isobenzofuran-1(3H),2'-[2H]pyran]-3',4',5'-triol, 6-[(4-ethylphenyl)methyl]-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)-, (1S,3'R,4'S,5'S,6'R)-

参考文献

1. Suzuki M, et al. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.

2. Ohtake Y, et al. J Med Chem. 2012 Sep 13;55(17):7828-40.

3. Nagata T, et al. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E414-23.

4. Nagata T, et al. Br J Pharmacol. 2013 Oct;170(3):519-31.

Tofogliflozin (CSG452, CSG-452)

生物&药学活性

物理化学性质&存储条件

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Tofogliflozin (CSG452, CSG-452)

生物&药学活性

物理化学性质&存储条件

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