Tofimilast |CAS:185954-27-2 Probechem Biochemicals

Chemical Structure : Tofimilast

CAS No.: 185954-27-2

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Tofimilast (CP-325366, CP325366)

货号: PC-63090Not For Human Use, Lab Use Only.

Tofimilast (CP-325366) is a potent, selective PDE4 inhibitor with IC50 of 23, 13 and 13 nM for PDE4A, PDE4B, and PDE4D, respectively.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

Tofimilast (CP-325366) is a potent, selective PDE4 inhibitor with IC50 of 23, 13 and 13 nM for PDE4A, PDE4B, and PDE4D, respectively.
Tofimilast (CP-325366) shows weakly or no inhibition for PDE4C, and no activity for PDE1, PDE2, PDE3, PDE5, PDE6, and PDE7.
Tofimilast (CP-325366) increases cAMP levels in PGE1-stimulated U937 cells with an EC50 of 230 nM, inhibits human monocyte PDE mediated cAMP catabolism with an IC50 of 67 nM and LPS stimulated human monocyte TNFα release with an IC50 of 59 nM.
Tofimilast (CP-325366) shows low oral bioavailability and no emesis-associated behaviors in the ferret emesis model.

物理化学性质&存储条件

分子量	339.461
分子式	C18H21N5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-Cyclopentyl-7-ethyl-3-(thiophen-2-yl)-6,9-dihydro-5H-pyrazolo(3,4-c)-1,2,4-triazolo(4,3-a)pyridine

参考文献

1. Duplantier AJ, et al. J Med Chem. 2007 Jan 25;50(2):344-9.

2. Giembycz MA. Br J Pharmacol. 2008 Oct;155(3):288-90.

Tofimilast (CP-325366, CP325366)

生物&药学活性

物理化学性质&存储条件

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Tofimilast (CP-325366, CP325366)

生物&药学活性

物理化学性质&存储条件

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