Tofacitinib citrate |CAS:540737-29-9 Probechem Biochemicals

Chemical Structure : Tofacitinib citrate

CAS No.: 540737-29-9

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Tofacitinib citrate (Tasocitinib citrate;CP-690550 citrate;CP 690550 citrate;CP690550 citrate)

货号: PC-45817Not For Human Use, Lab Use Only.

A potent, specific, orally active inhibitor of JAK3 with IC50 of 1 nM in cell-free assays.

规格	价格	库存
50 mg	￥640	In stock
100 mg	￥880	In stock
200 mg	￥1200	In stock
500 mg		Get quote

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生物&药学活性

A potent, specific, orally active inhibitor of JAK3 with IC50 of 1 nM in cell-free assays; displays 20- to 100-fold less potency for JAK2 and JAK1 (IC50=20 nM and 112 nM, respectively), and shows no potent activity against 30 other kinases at >3 uM (CaMK1, ROCK2, Lck, MST2, etc.); effectively inhibits a murine mixed lymphocyte reaction (MLR) with IC50 of 91 nM, significantly prolonges survival in a murine model of heart transplantation and in cynomolgus monkeys receiving kidney transplants.

Rheumatoid Arthritis

Approved

物理化学性质&存储条件

分子量	504.4931
分子式	C22H28N6O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 122.5 mg/mL
Chemical Name/SMILES	1-Piperidinepropanenitrile, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-, (3R,4R)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

参考文献

1. Changelian PS, et al. Science. 2003 Oct 31;302(5646):875-8.

2. Jiang JK, et al. J Med Chem. 2008 Dec 25;51(24):8012-8.

3. Kudlacz E, et al. Am J Transplant. 2004 Jan;4(1):51-7.

Tofacitinib citrate (Tasocitinib citrate;CP-690550 citrate;CP 690550 citrate;CP690550 citrate)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

Tofacitinib citrate (Tasocitinib citrate;CP-690550 citrate;CP 690550 citrate;CP690550 citrate)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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