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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-Tipranavir
Tipranavir

Chemical Structure : Tipranavir

CAS No.: 174484-41-4

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Tipranavir (PNU-140690, PNU140690)

货号: PC-21699Not For Human Use, Lab Use Only.

Tipranavir (PNU-140690) is a potent, nonpeptidic and orally bioavailable HIV protease inhibitor with Ki vaule of 8 pM, shows an IC90 value of 100 nM in antiviral cell culture.

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5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Tipranavir (PNU-140690) is a potent, nonpeptidic and orally bioavailable HIV protease inhibitor with Ki vaule of 8 pM, shows an IC90 value of 100 nM in antiviral cell culture.
Tipranavir (PNU-140690) has excellent potency against a variety of HIV type 1 (HIV-1) laboratory strains and clinical isolates, including those resistant to the reverse transcriptase inhibitors zidovudine or delavirdine.
Tipranavir (PNU-140690) contributes to synergistic antiviral activity, when combined with either zidovudine or delavirdine.
Tipranavir (PNU-140690) is also highly active against HIV-1 variants resistant to peptidomimetic protease inhibitors.

物理化学性质&存储条件

分子量 602.67
分子式 C31H33F3N2O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

rel-N-(3-((R)-1-((R)-4-hydroxy-2-oxo-6-phenethyl-6-propyl-5,6-dihydro-2H-pyran-3-yl)propyl)phenyl)-5-(trifluoromethyl)pyridine-2-sulfonamide

参考文献

1. Turner SR, et al. J Med Chem. 1998 Aug 27;41(18):3467-76.

2. Poppe SM, et al. Antimicrob Agents Chemother. 1997 May;41(5):1058-63.

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