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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Nucleoside Antimetabolite/Analog-Tipiracil hydrochloride
Tipiracil hydrochloride

Chemical Structure : Tipiracil hydrochloride

CAS No.: 183204-72-0

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Tipiracil hydrochloride (TPase inhibitor TPI, Thymidine Phosphorylase inhibitor TPI)

货号: PC-35966Not For Human Use, Lab Use Only.

Tipiracil hydrochloride (TPase inhibitor TPI) is a potent, selective inhibitor of thymidine phosphorylase (TPase) with Ki of 17 nM, does not inhibit uridine phosphorylase, thymidine kinase, orotate phosphoribosyltransferase, or dihydropyrimidine dehydrogenase.

规格 价格 库存 数量
5 mg (Free Sample) ￥280 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg ￥3280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Tipiracil hydrochloride (TPase inhibitor TPI) is a potent, selective inhibitor of thymidine phosphorylase (TPase) with Ki of 17 nM, does not inhibit uridine phosphorylase, thymidine kinase, orotate phosphoribosyltransferase, or dihydropyrimidine dehydrogenase.
Oral administration of TPI significantly potentiated the antitumor activity of F(3)dThd on AZ-521 human stomach cancer xenografts in nude mice.

物理化学性质&存储条件

分子量 279.121
分子式 C9H12Cl2N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione hydrochloride

参考文献

1. Fukushima M, et al. Biochem Pharmacol. 2000 May 15;59(10):1227-36.

2. Sperotto N, et al. J Med Chem. 2019 Jan 7. doi: 10.1021/acs.jmedchem.8b01305.

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