Tim-3 inhibitor ML-T7 | TIM-3 inhibitor | Probechem Biochemicals

Chemical Structure : Tim-3 inhibitor ML-T7

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Tim-3 inhibitor ML-T7 (ML-T7)

货号: PC-21328Not For Human Use, Lab Use Only.

Tim-3 inhibitor ML-T7 is a potent small molecule inhibitor of T cell immunoglobulin and mucin-containing molecule 3 (Tim-3), binds to Tim-3 disrupts the interaction of Tim-3 with PtdSer and CEACAM1.

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生物&药学活性

Tim-3 inhibitor ML-T7 is a potent small molecule inhibitor of T cell immunoglobulin and mucin-containing molecule 3 (Tim-3), binds to Tim-3 disrupts the interaction of Tim-3 with PtdSer and CEACAM1.
ML-T7 targets the FG-CC' cleft of Tim-3, a highly conserved binding site of phosphatidylserine (PtdSer) and carcinoembryonic antigen–related cell adhesion molecule 1 (CEACAM1).
ML-T7 binds to hTim-3 and mTim-3 with Kd (dissociation constant) values of 6.98 and 7.40 μM, respectively.
ML-T7 blocks hTim-3 binding to CEACAM1-overexpressing Jurkat cells in a concentration-dependent manner and directly disrupts CEACAM1 binding to hTim-3 in SPR assay.
ML-T7 does not block Tim-3/galectin-9 interaction.
ML-T7 enhances TCR/STAT5 signaling and promotes CD8+ T cell antitumor activity through Tim-3.
ML-T7 directly potentiates the survival and prevents exhaustion of CD8+ cytotoxic T lymphocytes (CTLs), potentiates functions of DCs through both Tim-3 and Tim-4.
ML-T7 (50 mg/kg) exerts antitumor activity in preclinical syngeneic mouse models and humanized mice, potentiates anti–PD-1 therapy in vivo.

物理化学性质&存储条件

分子量	506.34
分子式	C27H17Cl2NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2,4-dichlorophenyl)-3-(p-tolyl)-3a,6a-dihydrospiro[furo[3,4-c]pyrrole-1,2'-indene]-1',3',4,6(3H,5H)-tetraone

参考文献

1. Ma S, et al. Sci Transl Med. 2023 Nov 15;15(722):eadg6752.

Tim-3 inhibitor ML-T7 (ML-T7)

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Tim-3 inhibitor ML-T7 (ML-T7)

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