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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MEKK (MAP3K)-Tilpisertib fosmecarbil TFA
Tilpisertib fosmecarbil TFA

Chemical Structure : Tilpisertib fosmecarbil TFA

CAS No.: 2567459-65-6

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Tilpisertib fosmecarbil TFA (GS-5290 TFA)

货号: PC-27856Not For Human Use, Lab Use Only.

Tilpisertib fosmecarbil TFA (GS-5290) is an intestinally cleaved prodrug of GS-4875, a potent tumor progression locus 2 (TPL2 , COT, MAP3K8) inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Tilpisertib fosmecarbil TFA (GS-5290) is an intestinally cleaved prodrug of GS-4875, a potent tumor progression locus 2 (TPL2 , COT, MAP3K8) inhibitor.

物理化学性质&存储条件

分子量 861.16
分子式 C37H37ClF3N8O9P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(phosphonooxy)methyl (S)-((1-(bicyclo[1.1.1]pentan-1-yl)-1H-1,2,3-triazol-4-yl)(2-methyl-1-oxo-1,2-dihydroisoquinolin-5-yl)methyl)(8-chloro-3-cyano-4-(neopentylamino)quinolin-6-yl)carbamate TFA salt

参考文献

1. Priyanka A Madia, et al. J Clin Pharmacol. 2026 Aug;66(8):e70269.

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