Tilmacoxib |CAS:180200-68-4 Probechem Biochemicals

Chemical Structure : Tilmacoxib

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Tilmacoxib (JTE-522, RWJ57504)

货号: PC-62672Not For Human Use, Lab Use Only.

Tilmacoxib (JTE-522) is a potent, selective inhibitor of cyclooxygenase-2 (COX-2) that inhibits human recombinant COX-2 with IC50 of 85 nM, dispalys no activity against COX-1 (IC50>100 uM).

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生物&药学活性

Tilmacoxib (JTE-522) is a potent, selective inhibitor of cyclooxygenase-2 (COX-2) that inhibits human recombinant COX-2 with IC50 of 85 nM, dispalys no activity against COX-1 (IC50>100 uM).
Tilmacoxib significantly inhibits fibrosis, also inhibits growth of pulmonary metastases of colorectal cancer in rats.

物理化学性质&存储条件

分子量	338.397
分子式	C16H19FN2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-cyclohexyl-2-methyl-1,3-oxazol-5-yl)-2-fluorobenzenesulfonamide

参考文献

1. Wakitani K, et al. Jpn J Pharmacol. 1998 Nov;78(3):365-71.

2. Kobayashi H, et al. BMC Cancer. 2005 Mar 3;5:26.

3. Yamamoto H, et al. Gastroenterology. 2003 Aug;125(2):556-71.

Tilmacoxib (JTE-522, RWJ57504)

生物&药学活性

物理化学性质&存储条件

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Tilmacoxib (JTE-522, RWJ57504)

生物&药学活性

物理化学性质&存储条件

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